Endocrine Abstracts

Primary vaginal malignancy is uncommon, accounting for about 2% of all gynecological tract cancers, with small-cell neuroendocrine carcinoma of the vagina being exceptionally rare and aggressive. They display similar histological and immunohistochemical features to small-cell carcinomas of different origin. Few cases are reported in the literature so far and therefore, there is no current treatment protocol consensus. We report the case of a 34-year-old nulliparous patient, wh...

Introduction: Patients with inflammatory bowel disease (IBD) are at increased risk for decreased bone mass density (BMD), fractures. Preserved muscle mass is important for healthy bones. Low mean mass can be found in these patients due to immobilization, lack of physical activity and glucocorticoids. Our aim was to evaluate the presence of low BMD and muscle mass impact on it.Methods: 64 patients with inflammatory bowel disease (40 with Crohn disease, 24...

Background: A large body of evidences have demonstrated that metabolic surgery is associated with significant and durable weight loss as well as a significant improvement of obesity-related comorbidities. The aim of our study was to evaluate the long term impact of gastric sleeve on metabolic parameters in morbidly obese patients.Materials and methods: We evaluated 95 (67 women) severely obese patients (mean age 43.4±10.69 years) before and approxim...

Introduction: Vitamin D is a hormone essential for calcium absorption and bone mineralization, which is positively associated with bone mineral density. The aim of our study was to evaluate the relationship between 25-OH vitamin D values and parameters of bone mineralization (bone mineral density - BMD) and bone quality (trabecular bone score - TBS) in patients from day to day clinical practice.Materials and methods: We evaluated 433 postmenopausal women...

Introduction: Cushing disease is the most common cause of endogenous hypercortisolemia and most frequently is caused by microadenomas, but rarely, only in 10% to 20% of cases, the adenomas are large enough to produce mass effect.1Case report: We present the case of a 63 years old female patient, diagnosed in 2007 with a 22/18 mm non-secreting pituitary adenoma and panhypopituitarism. She undergone transsphenoidal surgery twice, followed by gam...

Introduction: Graves’ disease is an autoimmune disease that leads to a generalized overactivity of the entire thyroid gland – hyperthyroidism. Although the link between Graves’ disease and thyroid carcinoma was widely explored, we cannot undermine the relationship between this condition and other common neoplasms.Materials and method: The retrospective analysis was performed using clinical data of 295 adult patients (225 women and 70 men) ...

Introduction: Life expectancy is decreased in MEN1 patients due to multiple tumors that may be larger, more aggressive, resistant to treatment and with a higher risk of recurrence.Case report: We report a 59-year-old male patient with family history of endocrine tumors (father- pituitary adenoma, son- primary hyperparathyroidism, daughter- microprolactinoma, primary hyperparathyroidism). He was first referred to our Clinic in 2007 after being incidendall...

Background: Pituitary surgery is the first treatment option for acromegaly. The reported success of pituitary surgery varies between 75 and 95% for microadenomas and 45 and 68% for macroadenomas. The aim of this study was to report our experience regarding the remission rate after pituitary surgery in acromegaly patients.Methods: This retrospective study included 70 patients diagnosed with acromegaly in our clinic between 2009 and 2016. The criteria used...

Introduction: While the unfavourable metabolic consequences of obesity have been clearly demonstrated at a population level, there is a wealth of evidence indicating the existence of individuals somehow protected from developing complications, named ‘metabolically healthy obese’. The aim of our study was to identify clinical and biological parameters independently associated with ‘metabolically healthy’ status.Patients and methods: 44...

Aim of the study was to evaluate the relationship between biochemical bone turnover markers, calcium homeostasis parameters and the cardiovascular risk in patients with osteoporosis.Materials and methods: Subjects were 246 patients (mean age of 56.64) diagnosed with osteoporosis referred to the endocrine department of Elias Hospital, between 2009 and 2013, and who agreed with the terms of the study. Data collection consisted of clinica...